Price range: $268.00 through $328.00
Background:
function:Negative regulator of host innate immune defense against viruses. The repressor domain of DHX58 interacts with DDX58 and negatively regulates DDX58-mediated signaling. Binds dsRNA produced during viral replication, in particuliar HCV RNA., similarity:Belongs to the helicase family., similarity:Contains 1 helicase ATP-binding domain., similarity:Contains 1 helicase C-terminal domain., subunit:Interacts with DDX58 and probably blocks its homomultimerization.,
| Size | 50μL/100μL |
| Target | DHX58 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 74kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 451-500 |
| Specificity | DHX58 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DHX58 D11LGP2E LGP2 |
| Protein Name | Probable ATP-dependent RNA helicase DHX58 (Probable ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR) |
| Other Name | |
| Species | Human |
| Gene ID | 79132 |
| Uniprot | Q96C10, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99J87 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed in testis, nerve and spleen. Also expressed in the brain. |
| Signaling_pathway | Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway |
| Research Areas | >>RIG-I-like receptor signaling pathway |
| Function | Function:Negative regulator of host innate immune defense against viruses. The repressor domain of DHX58 interacts with DDX58 and negatively regulates DDX58-mediated signaling. Binds dsRNA produced during viral replication, in particuliar HCV RNA.,similarity:Belongs to the helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Interacts with DDX58 and probably blocks its homomultimerization., |
