Name: DLEC1 Polyclonal Antibody
SKU: WP12019
Price: 268 USD
Availability: InStock

DLEC1 Polyclonal Antibody

Ucallm_WP12019-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12019-100

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Product details

Background:

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016],

Specifications

Size	50μL/100μL
Target	DLEC1
Reactivity	Human, Mouse, Rat
Applications	IHC, IF, ELISA
MW(Calculated)	196kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human DLEC1. AA range:1-50
Specificity	DLEC1 Polyclonal Antibody detects endogenous levels of DLEC1 protein.
Gene Name	DLEC1
Protein Name	Deleted in lung and esophageal cancer protein 1
Other Name	DLEC1; / DLC1; / Deleted in lung and esophageal cancer protein 1; / Deleted in lung cancer protein 1; / DLC-1
Species	Human
Gene ID	9940
Uniprot	Q9Y238,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q8BLA1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm .
Tissue Expression	Expressed in all tissues examined. Expression is highest in prostate and testis.
Signaling_pathway
Research Areas
Function	Alternative products:At least six differentially spliced products may exist,Disease:Defects in DLEC1 may be a cause of breast cancer.,Disease:Defects in DLEC1 may be a cause of esophageal cancer [MIM:133239].,Disease:Defects in DLEC1 may be a cause of primary lung cancer [MIM:211980]. In 33% of lung, esophageal and renal cancer cell lines and primary cancers, there is a lack of functional transcripts and an increase in alternatively spliced non-functional transcripts; the gene itself is not altered.,Disease:Defects in DLEC1 may be a cause of renal cancer.,Function:May act as a tumor suppressor by inhibiting cell proliferation.,sequence Caution:Intron retention.,tissue specificity:Expressed in all tissues examined. Expression is highest in prostate and testis.,

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DLEC1 Polyclonal Antibody

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DLEC1 Polyclonal Antibody

Product details

Specifications

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