Price range: $268.00 through $328.00
Background:
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],
| Size | 50μL/100μL |
| Target | DNA2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 116kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DNA2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DNA2 DNA2L KIAA0083 |
| Protein Name | DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] |
| Other Name | |
| Species | Human |
| Gene ID | 1763 |
| Uniprot | P51530, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6ZQJ5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | D3ZG52 |
| Cellular Localization | Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). . |
| Tissue Expression | Bone marrow,Colon,Duodenum,Lymph, |
| Signaling_pathway | |
| Research Areas | >>DNA replication |
| Function | Function:May function in chromosomal DNA replication.,similarity:Belongs to the DNA2/NAM7 helicase family., |
