Product details
Background:
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DNAJC10 rabbit pAb
Ucallm_WP6104-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DNAJC10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 87kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DNAJC10 |
| Specificity | This antibody detects endogenous levels of DNAJC10 at Human, Mouse,Rat |
| Gene Name | DNAJC10 ERDJ5 UNQ495/PRO1012 |
| Protein Name | DnaJ homolog subfamily C member 10 (ER-resident protein ERdj5) (Macrothioredoxin) (MTHr) |
| Other Name | |
| Species | Human |
| Gene ID | 54431 |
| Uniprot | Q8IXB1, |
| Species.1 | Mouse |
| Gene ID.1 | 66861 |
| Uniprot.1 | Q9DC23, |
| Species.2 | Rat |
| Gene ID.2 | 295690 |
| Uniprot.2 | Q498R3 |
| Cellular Localization | Endoplasmic reticulum lumen . |
| Tissue Expression | |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | |
| Function | Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. |
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