Need Help? +(1)-866-986-9598
0 My Cart$0.00
Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/DNM3A Polyclonal Antibody
SKU: WP0594 Categories: ,

DNM3A Polyclonal Antibody

Ucallm_WP0594-50

Price range: $268.00 through $328.00

SKU: WP0594-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016],

Specifications

Size50μL/100μL
TargetDNM3A
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 10-90
SpecificityDNM3A Polyclonal Antibody detects endogenous levels of protein.
Gene NameDNMT3A
Protein NameDNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)
Other Name
SpeciesHuman
Gene ID1788
UniprotQ9Y6K1,
Species.1Mouse
Gene ID.1
Uniprot.1O88508,
Species.2Rat
Gene ID.2
Uniprot.2Q1LZ53
Cellular LocalizationNucleus . Chromosome . Cytoplasm . Accumulates in the major satellite repeats at pericentric heterochromatin. .
Tissue ExpressionHighly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Signaling_pathwayHuman Diseases >> Cancer: overview >> MicroRNAs in cancer
Research Areas>>Cysteine and methionine metabolism; / >>Metabolic pathways; / >>MicroRNAs in cancer
FunctionCatalytic activity:S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.,Caution:It is uncertain whether Met-1 or Met-4 is the initiator.,Function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones.,similarity:Belongs to the C5-methyltransferase family.,similarity:Contains 1 ADD-type zinc finger.,similarity:Contains 1 PWWP domain.,subunit:Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD-type zinc-finger (By similarity). Interacts with DNMT1 and DNMT3B. Interacts with the PRC2/EED-EZH2 complex.,tissue specificity:Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.,
Please login to post questions

Related products

J774A.1 whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Sku: WR4005
Categories: ,

U-Blot® CD86 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Western blot analysis of lysates from K562 cells, using α smooth muscle actin Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4021
Categories: ,

U-Blot® α smooth muscle actin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Western blot analysis of lysates from Hela cells, using MTCO2 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4017
Categories: ,

U-Blot® BID Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WM1140
Categories: ,

Acetyl Lysine Monoclonal Antibody [10B10]

0 Reviews
Price range: $288.00 through $368.00
Select options
Sku: WR4004
Categories: ,

U-Blot® Cleaved PARP1 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Western blot analysis of lysates from Hela cells, using Clathrin Heavy Chain 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4016
Categories: ,

U-Blot® Tuberin Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options

Customer Reviews

  • Shop Categories
Menu
Need Help? +(1)-866-986-9598
Back to Top
Product has been added to your cart