Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
| Size | 50μL/100μL |
| Target | DOCK7 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 235kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DOCK7 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DOCK7 KIAA1771 |
| Protein Name | Dedicator of cytokinesis protein 7 |
| Other Name | |
| Species | Human |
| Gene ID | 85440 |
| Uniprot | Q96N67, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8R1A4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell projection, axon . Enriched in the developing axons of hippocampal neurons. |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The DHR-2 domain mediates GEF activity.,Function:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,subcellular location:Enriched in the developing axons of hippocampal neurons.,subunit:Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.,tissue specificity:Widely expressed., |
