Product details
Background:
- Please choose product options by visiting S26A7 rabbit pAb.
- Please choose product options by visiting T179B rabbit pAb.
- Please choose product options by visiting HRI Polyclonal Antibody.
- Please choose product options by visiting MAP2 (Phospho Ser136) rabbit pAb.
DOM3Z rabbit pAb
Ucallm_WP6380-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DXO |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 44kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DOM3Z |
| Specificity | This antibody detects endogenous levels of DOM3Z at Human, Mouse,Rat |
| Gene Name | DOM3Z DOM3L NG6 |
| Protein Name | Protein Dom3Z (Dom-3 homolog Z) |
| Other Name | |
| Species | Human |
| Gene ID | 1797 |
| Uniprot | O77932, |
| Species.1 | Mouse |
| Gene ID.1 | 112403 |
| Uniprot.1 | O70348, |
| Species.2 | Rat |
| Gene ID.2 | 361799 |
| Uniprot.2 | Q6MG77 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA . The NAD-cap is present at the 5'-end of some RNAs and snoRNAs . In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay . Preferentially acts on NAD-capped transcripts in response to environmental stress . Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity). Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) . In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity). Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs . Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs . Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). |
Please login to post questions
Related products
