Product details
Background:
DPP8 rabbit pAb
Ucallm_WP8400-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DPP8 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 99kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DPP8 |
| Specificity | This antibody detects endogenous levels of DPP8 at Human, Mouse |
| Gene Name | DPP8 DPRP1 MSTP097 MSTP135 MSTP141 |
| Protein Name | Dipeptidyl peptidase 8 (DP8) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) |
| Other Name | |
| Species | Human |
| Gene ID | 54878 |
| Uniprot | Q6V1X1, |
| Species.1 | Mouse |
| Gene ID.1 | 74388 |
| Uniprot.1 | Q80YA7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 . Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 . Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation . The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). |
Please login to post questions
Related products
