DREB rabbit pAb
Ucallm_WP17531-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | DREB |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 71kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DREB AA range: 484-534 |
| Specificity | This antibody detects endogenous levels of DREB at Human/Mouse/Rat |
| Gene Name | DBN1 D0S117E |
| Protein Name | DREB |
| Other Name | |
| Species | Human |
| Gene ID | 1627 |
| Uniprot | Q16643, |
| Species.1 | Mouse |
| Gene ID.1 | 56320 |
| Uniprot.1 | Q9QXS6, |
| Species.2 | Rat |
| Gene ID.2 | 81653 |
| Uniprot.2 | Q07266 |
| Cellular Localization | Cytoplasm . Cell projection, dendrite . Cytoplasm, cell cortex . Cell junction . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). . |
| Tissue Expression | Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578). Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578). Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578). Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400). Expressed in the brain (PubMed:8216329, Ref.2). Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.,similarity:Contains 1 ADF-H domain.,subunit:Binds F-actin.,tissue specificity:Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas., |
Please login to post questions
Related products
