DUSP19 Polyclonal Antibody
Ucallm_WP12077-50
Price range: $268.00 through $328.00
Product details
Background:
dual specificity phosphatase 19(DUSP19) Homo sapiens Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009],
Specifications
| Size | 50μL/100μL |
| Target | DUSP19 |
| Reactivity | Human, Monkey |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DUSP19. AA range:111-160 |
| Specificity | DUSP19 Polyclonal Antibody detects endogenous levels of DUSP19 protein. |
| Gene Name | DUSP19 |
| Protein Name | Dual specificity protein phosphatase 19 |
| Other Name | DUSP19; / DUSP17; / LMWDSP3; / SKRP1; / Dual specificity protein phosphatase 19; / Dual specificity phosphatase TS-DSP1; / Low molecular weight dual specificity phosphatase 3; / LMW-DSP3; / Protein phosphatase SKRP1; / Stress-activated protein kinase pathway |
| Species | Human |
| Gene ID | 142679 |
| Uniprot | Q8WTR2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8K4T5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | |
| Tissue Expression | Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Has a dual specificity toward Ser/Thr and Tyr-containing proteins.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest., |
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