DYHC1 Polyclonal Antibody
Ucallm_WP1095-50
Price range: $268.00 through $328.00
Product details
Background:
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008],
Specifications
| Size | 50μL/100μL |
| Target | DYHC1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 511kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DYHC1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 |
| Protein Name | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) |
| Other Name | |
| Species | Human |
| Gene ID | 1778 |
| Uniprot | Q14204, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JHU4, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P38650 |
| Cellular Localization | Cytoplasm, cytoskeleton. |
| Tissue Expression | Brain,Epithelium,Foreskin,Lung,Placenta,Testis, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome |
| Research Areas | >>Phagosome; / >>Vasopressin-regulated water reabsorption; / >>Salmonella infection |
| Function | Domain:Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.,Function:Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.,similarity:Belongs to the dynein heavy chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains., |
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