EDG-4 Polyclonal Antibody
Ucallm_WP12114-50
Price range: $268.00 through $328.00
Product details
Background:
lysophosphatidic acid receptor 2(LPAR2) Homo sapiens This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | EDG-4 |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 39kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EDG4. AA range:271-320 |
| Specificity | EDG-4 Polyclonal Antibody detects endogenous levels of EDG-4 protein. |
| Gene Name | LPAR2 |
| Protein Name | Lysophosphatidic acid receptor 2 |
| Other Name | LPAR2; / EDG4; / LPA2; / Lysophosphatidic acid receptor 2; / LPA receptor 2; / LPA-2; / Lysophosphatidic acid receptor Edg-4 |
| Species | Human |
| Gene ID | 9170 |
| Uniprot | Q9HBW0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JL06 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell surface . Cell membrane; Multi-pass membrane protein . Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. |
| Tissue Expression | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>Rap1 signaling pathway; / >>Phospholipase D signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Pathogenic Escherichia coli infection; / >>Pathways in cancer |
| Function | Function:Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway.,miscellaneous:PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3.,tissue specificity:Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon., |
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