EEA1 Polyclonal Antibody
Ucallm_WP15127-50
Price range: $268.00 through $328.00
Product details
Background:
disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases., domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate., function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking., similarity:Contains 1 C2H2-type zinc finger., similarity:Contains 1 FYVE-type zinc finger., subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.,
Specifications
| Size | 50μL/100μL |
| Target | EEA1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 162kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EEA1. AA range:205-254 |
| Specificity | EEA1 Polyclonal Antibody detects endogenous levels of EEA1 protein. |
| Gene Name | EEA1 |
| Protein Name | Early endosome antigen 1 |
| Other Name | EEA1; / ZFYVE2; / Early endosome antigen 1; / Endosome-associated protein p162; / Zinc finger FYVE domain-containing protein 2 |
| Species | Human |
| Gene ID | 8411 |
| Uniprot | Q15075, |
| Species.1 | Mouse |
| Gene ID.1 | 216238 |
| Uniprot.1 | Q8BL66 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Early endosome membrane; Peripheral membrane protein. |
| Tissue Expression | Aorta,Cervix carcinoma,Fetal brain cortex,Skeletal muscle, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome |
| Research Areas | >>Endocytosis; / >>Phagosome; / >>Tuberculosis |
| Function | Disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.,Domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,Function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 FYVE-type zinc finger.,subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding., |
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