EF-G2 Polyclonal Antibody
Ucallm_WP12122-50
Price range: $268.00 through $328.00
Product details
Background:
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | EF-G2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 87kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GFM2. AA range:441-490 |
| Specificity | EF-G2 Polyclonal Antibody detects endogenous levels of EF-G2 protein. |
| Gene Name | GFM2 |
| Protein Name | Ribosome-releasing factor 2 mitochondrial |
| Other Name | GFM2; / EFG2; / MSTP027; / Ribosome-releasing factor 2; / mitochondrial; / RRF2mt; / Elongation factor G 2, mitochondrial; / EF-G2mt; / mEF-G 2; / Elongation factor G2; / hEFG2 |
| Species | Human |
| Gene ID | 84340 |
| Uniprot | Q969S9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8R2Q4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | translation, mitochondrion organization, cellular component disassembly, mitochondrial translation, ribosome disassembly, macromolecular complex disassembly, ribonucleoprotein complex disassembly, cellular macromolecular complex subunit organization, cellular macromolecular complex disassembly, macromolecular complex subunit organization, |
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