Name: Recombinant CD19 Fc-Fused Nanobody (VF0599)
SKU: WN0151
Price: 365 USD
Availability: InStock

Product details

Background:CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors.This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Specifications

Size	100μL
Target	CD19
Reactivity	Human
Applications	ELISA
MW(Calculated)
MW(Observed)
Host Species
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration	Please check the information on the tube
Clonality
Clone Number	VF0282
Immunogen	Purified recombinant Human CD19
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD19 protein.
Gene Name	CD19
Protein Name	B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
Other Name	B-lymphocyte antigen CD19; / Cd19; / Differentiation antigen CD19; / CD19; / Antibody deficiency due to defect in CD19 antibody; / Antibody deficiency due to defect in CD19; / included antibody; / AW495831 antibody; / B lymphocyte antigen CD19 antibody; / B lymphocyte surface antigen B4 antibody; / B-lymphocyte antigen CD19 antibody; / B-lymphocyte surface antigen B4 antibody; / B4 antibody; / CD19 antibody; / CD19 antigen antibody; / CD19 molecule antibody; / Cd19 protein antibody; / CD19_HUMAN antibody; / CVID3 antibody; / Differentiation antigen CD19 antibody; / Leu 12 antibody; / Leu-12 antibody; / Leu12 antibody; / MGC109570 antibody; / MGC12802 antibody; / T-cell surface antigen Leu-12 antibody
Species	Human
Gene ID	930
Uniprot	P15391,
Species.1	Mouse
Gene ID.1	13649
Uniprot.1	Q01279
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Membrane raft; Single-pass type I membrane protein .
Tissue Expression	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>EGFR tyrosine kinase inhibitor resistance; / >>Endocrine resistance; / >>MAPK signaling pathway; / >>ErbB signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>HIF-1 signaling pathway; / >>FoxO signaling pathway; / >>Phospholipase D signaling pathway; / >>Endocytosis; / >>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>Adherens junction; / >>Gap junction; / >>JAK-STAT signaling pathway; / >>Regulation of actin cytoskeleton; / >>GnRH signaling pathway; / >>Estrogen signaling pathway; / >>Oxytocin signaling pathway; / >>Relaxin signaling pathway; / >>Parathyroid hormone synthesis, secretion and action; / >>Cushing syndrome; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Shigellosis; / >>Hepatitis C; / >>Human cytomegalovirus infection; / >>Human papillomavirus infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>MicroRNAs in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Chemical carcinogenesis - reactive oxygen species; / >>Colorectal cancer; / >>Pancreatic cancer; / >>Endometrial cancer; / >>Glioma; / >>Prostate cancer; / >>Melanoma; / >>Bladder cancer; / >>Non-small cell lung cancer; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer; / >>Central carbon metabolism in cancer; / >>Choline metabolism in cancer; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer
Function	Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .