Product details
Background:
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011],
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EI2BB Polyclonal Antibody
Ucallm_WP1866-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | EI2BB |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 50-130 |
| Specificity | EI2BB Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | EIF2B2 EIF2BB |
| Protein Name | Translation initiation factor eIF-2B subunit beta (S20I15) (S20III15) (eIF-2B GDP-GTP exchange factor subunit beta) |
| Other Name | |
| Species | Human |
| Gene ID | 8892 |
| Uniprot | P49770, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99LD9, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q62818 |
| Cellular Localization | cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex, |
| Tissue Expression | Brain,Lung,Placenta, |
| Signaling_pathway | |
| Research Areas | >>Herpes simplex virus 1 infection |
| Function | Disease:Defects in EIF2B2 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.,Function:Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.,similarity:Belongs to the EIF-2B alpha/beta/delta subunits family.,subunit:Complex of five different subunits; alpha, beta, gamma, delta and epsilon., |
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