Product details
Background:
EIF3C rabbit pAb
Ucallm_WP8506-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | EIF3C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 100kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human EIF3C |
| Specificity | This antibody detects endogenous levels of EIF3C at Human, Mouse,Rat |
| Gene Name | EIF3C EIF3S8; EIF3CL |
| Protein Name | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) |
| Other Name | |
| Species | Human |
| Gene ID | 8663 |
| Uniprot | Q99613, |
| Species.1 | Mouse |
| Gene ID.1 | 56347 |
| Uniprot.1 | Q8R1B4, |
| Species.2 | Rat |
| Gene ID.2 | 293484 |
| Uniprot.2 | B5DFC8 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . |
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