Price range: $268.00 through $328.00
Background:
cRequired for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5′-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F., similarity:Contains 1 RRM (RNA recognition motif) domain., subunit:Self-associates and interacts with EIF3 p170 subunit.
| Size | 50μL/100μL |
| Target | eIF4B |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | |
| MW(Observed) | 69kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC1:50-200; WB 1:1000-2000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Eif4b AA range: 209-259 |
| Specificity | This antibody detects endogenous levels of Eif4b at Human, Mouse,Rat |
| Gene Name | EIF4B |
| Protein Name | Eif4b |
| Other Name | Eukaryotic translation initiation factor 4B; / eIF-4B |
| Species | Human |
| Gene ID | 1975 |
| Uniprot | P23588, |
| Species.1 | Mouse |
| Gene ID.1 | 75705 |
| Uniprot.1 | Q8BGD9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body, |
| Tissue Expression | Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>mTOR signaling pathway; / >>PI3K-Akt signaling pathway; / >>Proteoglycans in cancer |
| Function | Function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit., |
