Name: U-Blot® Catenin-α1 Rabbit mAb
SKU: WR5115
Price: 268 USD
Availability: InStock

U-Blot® Catenin-α1 Rabbit mAb

Ucallm_WR5115-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR5115-50

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Product details

Background:catenin alpha 1(CTNNA1) Homo sapiens This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016],

Specifications

Size	50μL/100μL
Target	Catenin-α1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	100kD
MW(Observed)	100kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1317R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	CTNNA1
Protein Name	Catenin alpha-1
Other Name	CTNNA1; / Catenin alpha-1; / Alpha E-catenin; / Cadherin-associated protein; / Renal carcinoma antigen NY-REN-13
Species	Human
Gene ID	1495
Uniprot	P35221,
Species.1	Mouse
Gene ID.1	12385
Uniprot.1	P26231
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	[Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side .
Tissue Expression	Expressed ubiquitously in normal tissues.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Endometrial cancer;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Research Areas	>>Hippo signaling pathway; / >>Adherens junction; / >>Leukocyte transendothelial migration; / >>Bacterial invasion of epithelial cells; / >>Pathways in cancer; / >>Endometrial cancer; / >>Gastric cancer; / >>Arrhythmogenic right ventricular cardiomyopathy
Function	Disease:Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,Function:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.,PTM:Sumoylated.,similarity:Belongs to the vinculin/alpha-catenin family.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,subunit:Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB.,tissue specificity:Expressed ubiquitously in normal tissues.,