Name: Elongin A2/3 Polyclonal Antibody
SKU: WP12161
Price: 268 USD
Availability: InStock

Elongin A2/3 Polyclonal Antibody

Ucallm_WP12161-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12161-100

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Product details

Background:

This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Elongin A2/3
Reactivity	Human
Applications	IF, ELISA
MW(Calculated)	84kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications;
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ELOA2. AA range:101-150
Specificity	Elongin A2/3 Polyclonal Antibody detects endogenous levels of Elongin A2/3 protein.
Gene Name	TCEB3B/TCEB3C
Protein Name	RNA polymerase II transcription factor SIII subunit A2/3
Other Name	TCEB3B; / TCEB3L; / RNA polymerase II transcription factor SIII subunit A2; / Elongin-A2; / EloA2; / Transcription elongation factor B polypeptide 3B; / TCEB3C; / TCEB3L2; / RNA polymerase II transcription factor SIII subunit A3; / Elongin-A3; / EloA3; / Transcr
Species	Human
Gene ID	51224;162699
Uniprot	Q8IYF1;Q8NG57
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Specifically expressed in testis.
Signaling_pathway
Research Areas
Function	Domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,Function:SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Heterotrimer of an A (A1, A2 or A3), B and C subunit.,tissue specificity:Specifically expressed in testis.,