Eme1 Polyclonal Antibody
Ucallm_WP12169-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
Specifications
| Size | 50μL/100μL |
| Target | Eme1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Eme1 . at AA range: 250-330 |
| Specificity | Eme1 Polyclonal Antibody detects endogenous levels of Eme1 protein. |
| Gene Name | EME1 |
| Protein Name | Crossover junction endonuclease EME1 |
| Other Name | EME1; / MMS4; / Crossover junction endonuclease EME1; / MMS4 homolog; / hMMS4 |
| Species | Human |
| Gene ID | 146956 |
| Uniprot | Q96AY2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BJW7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleolus . Recruited to regions of DNA damage in S-phase cells. |
| Tissue Expression | Epithelium,Placenta, |
| Signaling_pathway | |
| Research Areas | >>Homologous recombination; / >>Fanconi anemia pathway |
| Function | cofactor:Magnesium.,Function:Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.,similarity:Belongs to the EME1/MMS4 family.,subcellular location:Recruited to regions of DNA damage in S-phase cells.,subunit:May self-associate. Interacts with MUS81. Interacts with ERCC4 and FANCM., |
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