Endo180 Polyclonal Antibody
Ucallm_WP12182-50
Price range: $268.00 through $328.00
Product details
Background:
mannose receptor C type 2(MRC2) Homo sapiens This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012],
Specifications
| Size | 50μL/100μL |
| Target | Endo180 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 167kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MRC2. AA range:121-170 |
| Specificity | Endo180 Polyclonal Antibody detects endogenous levels of Endo180 protein. |
| Gene Name | MRC2 |
| Protein Name | C-type mannose receptor 2 |
| Other Name | MRC2; / CLEC13E; / ENDO180; / KIAA0709; / UPARAP; / C-type mannose receptor 2; / C-type lectin domain family 13 member E; / Endocytic receptor 180; / Macrophage mannose receptor 2; / Urokinase-type plasminogen activator receptor-associated protein; / UPAR-asso |
| Species | Human |
| Gene ID | 9902 |
| Uniprot | Q9UBG0, |
| Species.1 | Mouse |
| Gene ID.1 | 17534 |
| Uniprot.1 | Q64449, |
| Species.2 | Rat |
| Gene ID.2 | 498011 |
| Uniprot.2 | Q4TU93 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome |
| Research Areas | >>Phagosome; / >>Tuberculosis |
| Function | Domain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,Domain:Fibronectin type-II domain mediates collagen-binding.,Domain:Ricin B-type lectin domain contacts with the second C-type lectin domain.,Function:May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).,online information:Endo180,PTM:N-glycosylated.,PTM:Phosphorylated.,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,subunit:Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.,tissue specificity:Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney., |
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