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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Epac Polyclonal Antibody
SKU: WP12196 Categories: ,

Epac Polyclonal Antibody

Ucallm_WP12196-50

Price range: $268.00 through $328.00

SKU: WP12196-100
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Product details

Background:

caution:It is uncertain whether Met-1 or Met-43 is the initiator., domain:The DEP domain is involved in membrane localization independent from regulation by cAMP., function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP., similarity:Contains 1 cyclic nucleotide-binding domain., similarity:Contains 1 DEP domain., similarity:Contains 1 N-terminal Ras-GEF domain., similarity:Contains 1 Ras-GEF domain., tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,

Specifications

Size50μL/100μL
TargetEpac
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human RAPGEF3. AA range:712-761
SpecificityEpac Polyclonal Antibody detects endogenous levels of Epac protein.
Gene NameRAPGEF3
Protein NameRap guanine nucleotide exchange factor 3
Other NameRAPGEF3; / CGEF1; / EPAC; / EPAC1; / Rap guanine nucleotide exchange factor 3; / Exchange factor directly activated by cAMP 1; / Exchange protein directly activated by cAMP 1; / EPAC 1; / Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
SpeciesHuman
Gene ID10411
UniprotO95398,
Species.1Mouse
Gene ID.1223864
Uniprot.1Q8VCC8,
Species.2Rat
Gene ID.259326
Uniprot.2Q9Z1C8
Cellular LocalizationEndomembrane system .
Tissue ExpressionWidely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Signaling_pathwayOrganismal Systems >> Immune system >> Leukocyte transendothelial migration;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas>>Rap1 signaling pathway; / >>cAMP signaling pathway; / >>Phospholipase D signaling pathway; / >>Adrenergic signaling in cardiomyocytes; / >>Leukocyte transendothelial migration; / >>Long-term potentiation; / >>Serotonergic synapse
FunctionCaution:It is uncertain whether Met-1 or Met-43 is the initiator.,Domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,Function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,
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