SKU: WM0161 Categories: ,

EphA3 Monoclonal Antibody

Price range: $268.00 through $328.00

SKU: WM0161-50
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Product details

Background:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Specifications

Size50μL/100μL
TargetEphA3
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)110kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number20C7
ImmunogenPurified recombinant fragment of EphA3 (aa751-983) expressed in E. Coli.
SpecificityEphA3 Monoclonal Antibody detects endogenous levels of EphA3 protein.
Gene NameEPHA4
Protein NameEphrin type-A receptor 4
Other NameEPHA4; / HEK8; / SEK; / TYRO1; / Ephrin type-A receptor 4; / EPH-like kinase 8; / EK8; / hEK8; / Tyrosine-protein kinase TYRO1; / Tyrosine-protein kinase receptor SEK
SpeciesHuman
Gene ID2043
UniprotP54764,
Species.1Mouse
Gene ID.1
Uniprot.1Q03137
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density membrane . Early endosome . Cell junction, adherens junction . Clustered upon activation and targeted to early endosome. .
Tissue ExpressionUbiquitous.
Signaling_pathway
Research Areas>>Axon guidance
FunctionCatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Domain:The protein kinase domain mediates interaction with NGEF/ephexin-1.,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1.,tissue specificity:Ubiquitous.,
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