EphA7 Monoclonal Antibody
Ucallm_WM0165-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
Specifications
| Size | 50μL/100μL |
| Target | EPHA7 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 112kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 16C1 |
| Immunogen | Purified recombinant fragment of EphA7 (aa27-210) expressed in E. Coli. |
| Specificity | EphA7 Monoclonal Antibody detects endogenous levels of EphA7 protein. |
| Gene Name | EPHA7 |
| Protein Name | Ephrin type-A receptor 7 |
| Other Name | EPHA7; / EHK3; / HEK11; / Ephrin type-A receptor 7; / EPH homology kinase 3; / EHK-3; / EPH-like kinase 11; / EK11; / hEK11 |
| Species | Human |
| Gene ID | 2045 |
| Uniprot | Q15375, |
| Species.1 | Mouse |
| Gene ID.1 | 13841 |
| Uniprot.1 | Q61772 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with PRKCABP and GRIP1.,tissue specificity:Widely expressed., |
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