SKU: WP12217 Categories: ,

Ephrin-A4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12217-100
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Product details

Background:

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetEphrin-A4
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)95kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human EFNA4. AA range:131-180
SpecificityEphrin-A4 Polyclonal Antibody detects endogenous levels of Ephrin-A4 protein.
Gene NameEFNA4 EPLG4 LERK4
Protein NameEphrin-A4
Other NameEFNA4; / EPLG4; / LERK4; / Ephrin-A4; / EPH-related receptor tyrosine kinase ligand 4; / LERK-4
SpeciesHuman
Gene ID1945
UniprotP52798,
Species.1Mouse
Gene ID.113639
Uniprot.1O08542
Species.2
Gene ID.2
Uniprot.2
Cellular Localization[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted .
Tissue ExpressionExpressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
Signaling_pathwayHuman Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas>>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>PI3K-Akt signaling pathway; / >>Axon guidance; / >>MicroRNAs in cancer
FunctionFunction:May play a role in the interaction between activated B lymphocytes and dendritic cells in tonsils.,similarity:Belongs to the ephrin family.,tissue specificity:Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.,
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