Price range: $268.00 through $328.00
Background:
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008],
| Size | 50μL/100μL |
| Target | Eps8L2 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 81kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ES8L2. AA range:1-50 |
| Specificity | Eps8L2 Polyclonal Antibody detects endogenous levels of Eps8L2 protein. |
| Gene Name | EPS8L2 |
| Protein Name | Epidermal growth factor receptor kinase substrate 8-like protein 2 |
| Other Name | EPS8L2; / EPS8R2; / PP13181; / Epidermal growth factor receptor kinase substrate 8-like protein 2; / EPS8-like protein 2; / Epidermal growth factor receptor pathway substrate 8-related protein 2; / EPS8-related protein 2 |
| Species | Human |
| Gene ID | 64787 |
| Uniprot | Q9H6S3, |
| Species.1 | Mouse |
| Gene ID.1 | 98845 |
| Uniprot.1 | Q99K30 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cell projection, stereocilium . Localizes at the tips of the stereocilia of the inner and outer hair cells. . |
| Tissue Expression | Detected in fibroblasts and placenta. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.,tissue specificity:Detected in fibroblasts and placenta., |
