ERD21 Polyclonal Antibody
Ucallm_WP1128-50
Price range: $268.00 through $328.00
Product details
Background:
KDEL endoplasmic reticulum protein retention receptor 1(KDELR1) Homo sapiens Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to t
Specifications
| Size | 50μL/100μL |
| Target | ERD21 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | ERD21 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KDELR1 ERD2.1 |
| Protein Name | ER lumen protein retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23) |
| Other Name | |
| Species | Human |
| Gene ID | 10945 |
| Uniprot | P24390, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99JH8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q569A6 |
| Cellular Localization | Golgi apparatus membrane; Multi-pass membrane protein . Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein . Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. . |
| Tissue Expression | Lung fibroblast,Muscle,Placenta,Skin, |
| Signaling_pathway | |
| Research Areas | >>Vibrio cholerae infection |
| Function | Function:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi.,Function:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.,similarity:Belongs to the ERD2 family.,subunit:Interacts with ARFGAP1., |
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