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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ETS1 Polyclonal Antibody
SKU: WP12258 Categories: ,

ETS1 Polyclonal Antibody

Ucallm_WP12258-50

Price range: $268.00 through $328.00

SKU: WP12258-100
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Product details

Background:

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],

Specifications

Size50μL/100μL
TargetETS1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)50kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human ETS1. AA range:11-60
SpecificityETS1 Polyclonal Antibody detects endogenous levels of ETS1 protein.
Gene NameETS1
Protein NameProtein C-ets-1
Other NameEts-1; / ETS1; / EWSR2; / Protein C-ets-1; / p54
SpeciesHuman
Gene ID2113
UniprotP14921,
Species.1Mouse
Gene ID.123871
Uniprot.1P27577,
Species.2Rat
Gene ID.224356
Uniprot.2P41156
Cellular LocalizationCytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .
Tissue ExpressionHighly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
Signaling_pathwayCellular Processes >> Cell growth and death >> Cellular senescence;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Renal cell carcinoma;Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Research Areas>>Ras signaling pathway; / >>Cellular senescence; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer; / >>Renal cell carcinoma
FunctionDisease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,Function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,
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