Product details
Background:
- Please choose product options by visiting EXOSC4 rabbit pAb.
- Please choose product options by visiting EYA2 rabbit pAb.
EVI5 rabbit pAb
Ucallm_WP17600-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | EVI5 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 89kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human EVI5 AA range: 1-51 |
| Specificity | This antibody detects endogenous levels of EVI5 at Human/Mouse |
| Gene Name | EVI5 NB4S |
| Protein Name | EVI5 |
| Other Name | |
| Species | Human |
| Gene ID | 7813 |
| Uniprot | O60447, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P97366 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis. |
| Tissue Expression | Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1; 10)(p22; q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.,Function:Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.,induction:Down-regulated during mitosis through proteasomal degradation.,miscellaneous:Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.,PTM:Probably phosphorylated by PLK1; may be required for degradation during mitosis.,PTM:Ubiquitinated. Degradation during prophase is ubiquitin-dependent.,similarity:Contains 1 Rab-GAP TBC domain.,subcellular location:Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.,subunit:Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.,tissue specificity:Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal., |
Please login to post questions
Related products
