FA11 (heavy chain, Cleaved-Glu19) rabbit pAb
Ucallm_WP0123-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | FA11 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD,66kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Glu19) |
| Specificity | This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Glu19, protein was cleaved amino acid sequence between 18-19 ) |
| Gene Name | F11 |
| Protein Name | FA11 (heavy chain, Cleaved-Glu19) |
| Other Name | Coagulation factor XI; / FXI; / Plasma thromboplastin antecedent; / PTA; / [Cleaved into: Coagulation factor XIa heavy chain; / Coagulation factor XIa light chain] |
| Species | Human |
| Gene ID | 2160 |
| Uniprot | P03951, |
| Species.1 | Mouse |
| Gene ID.1 | 109821 |
| Uniprot.1 | Q91Y47 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | >>Complement and coagulation cascades |
| Function | Catalytic activity:Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.,Disease:Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.,Function:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.,online information:Factor XI entry,PTM:Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.,tissue specificity:Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells., |
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