Price range: $268.00 through $328.00
Background:
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | FAF1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human FAF1. AA range:461-510 |
| Specificity | FAF1 Polyclonal Antibody detects endogenous levels of FAF1 protein. |
| Gene Name | FAF1 |
| Protein Name | FAS-associated factor 1 |
| Other Name | FAF1; / UBXD12; / UBXN3A; / CGI-03; / FAS-associated factor 1; / hFAF1; / UBX domain-containing protein 12; / UBX domain-containing protein 3A |
| Species | Human |
| Gene ID | 11124 |
| Uniprot | Q9UNN5, |
| Species.1 | Mouse |
| Gene ID.1 | 14084 |
| Uniprot.1 | P54731, |
| Species.2 | Rat |
| Gene ID.2 | 140657 |
| Uniprot.2 | Q924K2 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. |
| Signaling_pathway | |
| Research Areas | >>Necroptosis |
| Function | Function:Potentiates but cannot initiate FAS-induced apoptosis.,similarity:Contains 1 UBX domain.,subunit:Specifically interacts with the cytoplasmic domain of FAS.,tissue specificity:Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes., |
