Product details
Background:
- Please choose product options by visiting HA-Tag Monoclonal Antibody [1B10], AbFluor 594 Conjugated.
- Please choose product options by visiting HA-Tag Monoclonal Antibody [1B10], AbFluor 680 Conjugated.
- Please choose product options by visiting FAM118B rabbit pAb.
FAM107A rabbit pAb
Ucallm_WP6586-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FAM107A |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 16kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FAM107A |
| Specificity | This antibody detects endogenous levels of FAM107A at Human |
| Gene Name | FAM107A DRR1 TU3A |
| Protein Name | Protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A) |
| Other Name | |
| Species | Human |
| Gene ID | 11170 |
| Uniprot | O95990 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm, cytoskeleton, stress fiber . Cell junction, focal adhesion . Cell projection, ruffle membrane . Cell junction, synapse . Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869). . |
| Tissue Expression | Widely expressed (PubMed:10564580). Expressed in neurons (PubMed:20543869). Expressed in malignant glial tumors (PubMed:20543869). Expression is reduced or absent in a number of cancer cell lines (PubMed:10564580). |
| Signaling_pathway | |
| Research Areas | |
| Function | Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner . Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner . May play a role in tumor development . |
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