Product details
Background:
FAM62B rabbit pAb
Ucallm_WP7959-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ESYT2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 101kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FAM62B |
| Specificity | This antibody detects endogenous levels of FAM62B at Human, Mouse |
| Gene Name | ESYT2 FAM62B KIAA1228 |
| Protein Name | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) |
| Other Name | |
| Species | Human |
| Gene ID | 57488 |
| Uniprot | A0FGR8, |
| Species.1 | Mouse |
| Gene ID.1 | 52635 |
| Uniprot.1 | Q3TZZ7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437). . |
| Tissue Expression | Widely expressed with high level in cerebellum. |
| Signaling_pathway | |
| Research Areas | |
| Function | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) . |
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