Nucleus . Cytoplasm . Accumulates in aggresomes under proteasome inhibition conditions.
Tissue Expression
Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.
Signaling_pathway
Research Areas
Function
similarity:Contains 2 ubiquitin-like domains.,subunit:Interacts with MAD2.,