Product details
Background:
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FBP17 rabbit pAb
Ucallm_WP7937-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FNBP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 68kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FBP17 |
| Specificity | This antibody detects endogenous levels of FBP17 at Human, Mouse,Rat |
| Gene Name | FNBP1 FBP17 KIAA0554 |
| Protein Name | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) |
| Other Name | |
| Species | Human |
| Gene ID | 23048 |
| Uniprot | Q96RU3, |
| Species.1 | Mouse |
| Gene ID.1 | 14269 |
| Uniprot.1 | Q80TY0, |
| Species.2 | Rat |
| Gene ID.2 | 192348 |
| Uniprot.2 | Q8R511 |
| Cellular Localization | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. |
| Tissue Expression | Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
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