Product details
Background:
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FBXO11 rabbit pAb
Ucallm_WP7246-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FBXO11 |
| Reactivity | Human, Rat |
| Applications | WB |
| MW(Calculated) | 102kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein. AA range:1500-1500 |
| Specificity | This antibody detects endogenous levels of FBXO11 at Human,Rat |
| Gene Name | FBXO11 FBX11 VIT1 UG063H01 |
| Protein Name | F-box only protein 11 (Vitiligo-associated protein 1) (VIT-1) |
| Other Name | |
| Species | Human |
| Gene ID | 80204 |
| Uniprot | Q86XK2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TPD1, |
| Species.2 | Rat |
| Gene ID.2 | 301674 |
| Uniprot.2 | Q7TSL3 |
| Cellular Localization | Nucleus. Chromosome. |
| Tissue Expression | Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. |
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