Price range: $268.00 through $328.00
Background:
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | FCERG |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | 9kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FCERG AA range: 31-81 |
| Specificity | This antibody detects endogenous levels of FCERG at Human/Mouse/Rat |
| Gene Name | FCER1G |
| Protein Name | FCERG |
| Other Name | |
| Species | Human |
| Gene ID | 2207 |
| Uniprot | P30273, |
| Species.1 | Mouse |
| Gene ID.1 | 14127 |
| Uniprot.1 | P20491, |
| Species.2 | Rat |
| Gene ID.2 | 25441 |
| Uniprot.2 | P20411 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway;Human Diseases >> Immune disease >> Asthma;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | >>Sphingolipid signaling pathway; / >>Phospholipase D signaling pathway; / >>Platelet activation; / >>C-type lectin receptor signaling pathway; / >>Natural killer cell mediated cytotoxicity; / >>Fc epsilon RI signaling pathway; / >>Tuberculosis; / >>Asthma |
| Function | Function:Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.,similarity:Belongs to the CD3Z/FCER1G family.,similarity:Contains 1 ITAM domain.,subunit:IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A., |
