Price range: $268.00 through $328.00
Background:
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
| Size | 50μL/100μL |
| Target | FCGRT |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 40kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FCGRT AA range: 146-196 |
| Specificity | This antibody detects endogenous levels of FCGRT at Human/Mouse/Rat |
| Gene Name | FCGRT FCRN |
| Protein Name | FCGRN |
| Other Name | |
| Species | Human |
| Gene ID | 2217 |
| Uniprot | P55899, |
| Species.1 | Mouse |
| Gene ID.1 | 14132 |
| Uniprot.1 | Q61559, |
| Species.2 | Rat |
| Gene ID.2 | 29558 |
| Uniprot.2 | P13599 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Endosome membrane . |
| Tissue Expression | Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.,similarity:Belongs to the immunoglobulin superfamily.,subunit:FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer., |
