SKU: WP2545 Categories: ,

FCRL1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2545-100
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Product details

Background:

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],

Specifications

Size50μL/100μL
TargetFCRL1
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)47kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityFCRL1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameFCRL1 FCRH1 IFGP1 IRTA5
Protein NameFc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)
Other Name
SpeciesHuman
Gene ID115350
UniprotQ96LA6,
Species.1Mouse
Gene ID.1
Uniprot.1Q8R4Y0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type I membrane protein .
Tissue ExpressionPrimarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).
Signaling_pathway
Research Areas
FunctionFunction:May function as an activating coreceptor in B cells. May function in B cells activation and differentiation.,induction:Down-regulated in activated B cells.,PTM:Phosphorylated on tyrosines upon activation.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level).,
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