SKU: WP12288 Categories: ,

Fe65L Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12288-100
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Product details

Background:

amyloid beta precursor protein binding family B member 2(APBB2) Homo sapiens The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Specifications

Size50μL/100μL
TargetFe65L
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)83kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human APBB2. AA range:471-520
SpecificityFe65L Polyclonal Antibody detects endogenous levels of Fe65L protein.
Gene NameAPBB2
Protein NameAmyloid beta A4 precursor protein-binding family B member 2
Other NameAPBB2; / FE65L; / FE65L1; / Amyloid beta A4 precursor protein-binding family B member 2; / Protein Fe65-like 1
SpeciesHuman
Gene ID323
UniprotQ92870,
Species.1Mouse
Gene ID.111787
Uniprot.1Q9DBR4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum . Golgi apparatus . Early endosome .
Tissue ExpressionWidely expressed.
Signaling_pathway
Research Areas
FunctionFunction:May modulate the internalization of beta-amyloid precursor protein.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subunit:Binds to the intracellular domain of the beta-amyloid precursor protein.,
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