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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Rabbit mAb/U-Blot® Ferritin Heavy Chain Rabbit mAb
SKU: WR4192 Categories: ,

U-Blot® Ferritin Heavy Chain Rabbit mAb

Western blot analysis of lysates from U-14 cells, using Ferritin Heavy Chain Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
WR4192 Western blot analysis of lysates from U-14 cells, using Ferritin Heavy Chain Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

SKU: WR4192-50
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Product details

Background:This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetFerritin heavy chain
ReactivityHuman, Mouse, Rat, Zebrafish
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)21kD
MW(Observed)21kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:2000-1:10000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM0363R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameFTH1
Protein NameFerritin heavy chain
Other NameFTH1; / FTH; / FTHL6; / OK/SW-cl.84; / PIG15; / Ferritin heavy chain; / Ferritin H subunit; / Cell proliferation-inducing gene 15 protein
SpeciesHuman
Gene ID2495
UniprotP02794,
Species.1Mouse
Gene ID.114319
Uniprot.1P09528,
Species.2Rat
Gene ID.225319
Uniprot.2P19132
Cellular LocalizationCytoplasm
Tissue ExpressionExpressed in the liver.
Signaling_pathwayCellular Processes >> Cell growth and death >> Ferroptosis;Cellular Processes >> Cell growth and death >> Necroptosis
Research Areas>>Ferroptosis; / >>Necroptosis; / >>Mineral absorption
FunctionCatalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.,
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