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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/FGF-17 Polyclonal Antibody
SKU: WP15563 Categories: ,

FGF-17 Polyclonal Antibody

Ucallm_WP15563-50

Price range: $268.00 through $328.00

SKU: WP15563-100
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Product details

Background:

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],

Specifications

Size50μL/100μL
TargetFGF-17
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)25kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF17. AA range:267-216
SpecificityFGF-17 Polyclonal Antibody detects endogenous levels of FGF-17 protein.
Gene NameFGF17
Protein NameFibroblast growth factor 17
Other NameFGF17; / Fibroblast growth factor 17; / FGF-17
SpeciesHuman
Gene ID8822
UniprotO60258,
Species.1Mouse
Gene ID.1
Uniprot.1P63075
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted.
Tissue ExpressionPreferentially expressed in the embryonic brain.
Signaling_pathwayCellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas>>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Melanoma; / >>Breast cancer; / >>Gastric cancer
Functiondevelopmental stage:Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5.,Function:May be a signaling molecule in the induction and patterning of the embryonic brain.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Preferentially expressed in the embryonic brain.,
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