Name: FGF-23 Polyclonal Antibody
SKU: WP12298
Price: 268 USD
Availability: InStock

FGF-23 Polyclonal Antibody

Ucallm_WP12298-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12298-100

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Product details

Background:

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013],

Specifications

Size	50μL/100μL
Target	FGF-23
Reactivity	Human, Mouse, Rat
Applications	WB, IF, ELISA
MW(Calculated)
MW(Observed)	27kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; IF 1:100-300; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human FGF23. AA range:151-200
Specificity	FGF-23 Polyclonal Antibody detects endogenous levels of FGF-23 protein.
Gene Name	FGF23
Protein Name	Fibroblast growth factor 23
Other Name	FGF23; / HYPF; / Fibroblast growth factor 23; / FGF-23; / Phosphatonin; / Tumor-derived hypophosphatemia-inducing factor
Species	Human
Gene ID	8074
Uniprot	Q9GZV9,
Species.1	Mouse
Gene ID.1	64654
Uniprot.1	Q9EPC2,
Species.2	Rat
Gene ID.2	170583
Uniprot.2	Q8VI82
Cellular Localization	Secreted . Secretion is dependent on O-glycosylation.
Tissue Expression	Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Parathyroid hormone synthesis, secretion and action; / >>Pathways in cancer; / >>Melanoma; / >>Breast cancer; / >>Gastric cancer
Function	Disease:Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues.,Disease:Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses.,PTM:After secretion it is processed into a N-terminal fragment and a C-terminal fragment. The processing is effected by the proprotein convertases.,similarity:Belongs to the heparin-binding growth factors family.,