FGF Receptor 1 Monoclonal Antibody
Ucallm_WM0195-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome,
Specifications
| Size | 50μL/100μL |
| Target | FGF Receptor 1 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 120kD |
| MW(Observed) | full length 120-140kD,FOP-FGFR1 90kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 16B7 |
| Immunogen | Purified recombinant extracellular fragment of human Flg (aa22-376) fused with hIgGFc tag expressed in HEK293 cells. |
| Specificity | Flg Monoclonal Antibody detects endogenous levels of Flg protein. |
| Gene Name | FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR |
| Protein Name | Fibroblast growth factor receptor 1 |
| Other Name | FGFR1; / BFGFR; / CEK; / FGFBR; / FLG; / FLT2; / HBGFR; / Fibroblast growth factor receptor 1; / FGFR-1; / Basic fibroblast growth factor receptor 1; / BFGFR; / bFGF-R-1; / Fms-like tyrosine kinase 2; / FLT-2; / N-sam; / Proto-oncogene c-Fgr; / CD antigen CD331 |
| Species | Human |
| Gene ID | 2260 |
| Uniprot | P11362 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. |
| Tissue Expression | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Prostate cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Adherens junction; / >>Signaling pathways regulating pluripotency of stem cells; / >>Thermogenesis; / >>Regulation of actin cytoskeleton; / >>Parathyroid hormone synthesis, secretion and action; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Prostate cancer; / >>Melanoma; / >>Breast cancer; / >>Central carbon metabolism in cancer |
| Function | Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL (By similarity). A shorter form of the receptor could be a receptor for FGF1 (aFGF). |
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