FGFR1/2/3/4 rabbit pAb
Ucallm_WP17822-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome,
Specifications
| Size | 50μL/100μL |
| Target | FGF Receptor 1/2/3/4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 90kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FGFR1/2/3/4 |
| Specificity | This antibody detects endogenous levels of FGFR1/2/3/4 at Human, Mouse,Rat |
| Gene Name | FGFR1/2/3/4 |
| Protein Name | Fibroblast growth factor receptor 1/2/3/4 |
| Other Name | Fibroblast growth factor receptor 1; / FGFR-1; / Basic fibroblast growth factor receptor 1; / BFGFR; / bFGF-R-1; / Fms-like tyrosine kinase 2; / FLT-2; / N-sam; / Proto-oncogene c-Fgr; / CD antigen CD331; / FGFR-2; / FGFR-3; / FGFR-4 |
| Species | Human |
| Gene ID | 2260;2263;2261;2264 |
| Uniprot | P11362;P21802;P22607;P22455, |
| Species.1 | Mouse |
| Gene ID.1 | 14182;14183;14184;14186 |
| Uniprot.1 | P16092;P21803;Q61851;A0A0R4IZY3, |
| Species.2 | Rat |
| Gene ID.2 | 79114 |
| Uniprot.2 | Q04589 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. |
| Tissue Expression | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Bladder cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Adherens junction; / >>Signaling pathways regulating pluripotency of stem cells; / >>Thermogenesis; / >>Regulation of actin cytoskeleton; / >>Parathyroid hormone synthesis, secretion and action; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Prostate cancer; / >>Melanoma; / >>Breast cancer; / >>Central carbon metabolism in cancer |
| Function | Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL (By similarity). A shorter form of the receptor could be a receptor for FGF1 (aFGF).Receptor for acidic and basic fibroblast growth factors. |
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