Product details
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FKBP6 rabbit pAb
Ucallm_WP8883-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | FKBP6 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 36kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FKBP6 |
| Specificity | This antibody detects endogenous levels of FKBP6 at Human |
| Gene Name | FKBP6 FKBP36 |
| Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP6 (PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) (Rotamase) |
| Other Name | |
| Species | Human |
| Gene ID | 8468 |
| Uniprot | O75344, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91XW8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . Nucleus . Chromosome . Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity). . |
| Tissue Expression | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). |
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