Name: Fli-1 Polyclonal Antibody
SKU: WP12315
Price: 268 USD
Availability: InStock

Fli-1 Polyclonal Antibody

Ucallm_WP12315-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12315-100

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Product details

Background:

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Specifications

Size	50μL/100μL
Target	FLI1
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	50kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human FLI1. AA range:291-340
Specificity	Fli-1 Polyclonal Antibody detects endogenous levels of Fli-1 protein.
Gene Name	FLI1
Protein Name	Friend leukemia integration 1 transcription factor
Other Name	FLI1; / Friend leukemia integration 1 transcription factor; / Proto-oncogene Fli-1; / Transcription factor ERGB
Species	Human
Gene ID	2313
Uniprot	Q01543,
Species.1	Mouse
Gene ID.1	14247
Uniprot.1	P26323
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Blood,Bone marrow,Lymph,Placenta,
Signaling_pathway	Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Research Areas	>>Transcriptional misregulation in cancer
Function	Disease:A chromosomal aberration involving FLI1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(11; 22)(q24; q12) with EWS.,Function:Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.,miscellaneous:Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4; 11)(q21; q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11; 22) (q24; q12) breakpoint.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Can form homodimers or heterodimers with ETV6/TEL1.,