Flotillin-1 Monoclonal Antibody [6C10]
Ucallm_WM1064-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016],
Specifications
| Size | 50μL/100μL |
| Target | Flotillin-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 49kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 6C10 |
| Immunogen | Synthetic Peptide of Flotillin-1 |
| Specificity | The antibody detects endogenous Flotillin-1 protein. |
| Gene Name | FLOT1 |
| Protein Name | Flotillin-1 |
| Other Name | Flotillin-1 |
| Species | Human |
| Gene ID | 10211 |
| Uniprot | O75955 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Endosome . Membrane, caveola; Peripheral membrane protein . Melanosome . Membrane raft . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). . |
| Tissue Expression | Adipose tissue,Adrenal gland,Lung,Peripheral blood leukocyte,Umbilical cord blood, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Insulin signaling pathway |
| Research Areas | >>Insulin signaling pathway |
| Function | Function:May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.,similarity:Belongs to the band 7/mec-2 family. Flotillin subfamily.,subcellular location:Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2., |
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