SKU: WP1140 Categories: ,

FOLR3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1140-100
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Product details

Background:

This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

Specifications

Size50μL/100μL
TargetFOLR3
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)26kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityFOLR3 Polyclonal Antibody detects endogenous levels of protein.
Gene NameFOLR3
Protein NameFolate receptor gamma (FR-gamma) (Folate receptor 3)
Other Name
SpeciesHuman
Gene ID2352
UniprotP41439
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted.
Tissue ExpressionSpleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.
Signaling_pathway
Research Areas>>Antifolate resistance; / >>Endocytosis
FunctionFunction:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.,PTM:Eight disulfide bonds are present.,similarity:Belongs to the folate receptor family.,tissue specificity:Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.,
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